Down Syndrome Research and Practice Volume 3 Number 1 Pages 9-13
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چکیده
9 Introduction Lejeune et al, in 1959 were the first to demonstrate that Down syndrome was due to an abnormality of an extra chromosome in the G group. This was subsequently confirmed to be chromosome 21. Other studies followed demonstrating that the characteristic appearance of Down syndrome could also be due to other aberrations involving chromosome 21. These included Robertsonian translocations, usually 14/21 and 21/21 (Polani et al, 1960; Penrose et al, 1960), mosaicism (Clarke et al, 1961) and other mixoploids (Smith and Berg, 1976).
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Down Syndrome Research and Practice Volume 4 Number 1 Pages 25-36
25 Introduction Over the last ten years our laboratories at McMaster University, and more recently, Simon Fraser University and the University of Alberta, have been actively engaged in research concerned with cerebral organization in adults and adolescents with Down syndrome. Our goal has been to determine how patterns of brain organization unique to Down syndrome may contribute to both the spe...
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I will be mainly using the research results, coloured by my own experiences, from the Manchester Down syndrome Cohort Study which I started in 1973. I have been fortunate in being able to follow over 100 families over the years and the last project, completed by my colleagues Sloper and Turner (1994) investigated them in the teenage years. Currently we are visiting them again as they enter adul...
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© 1993,1999. The Down Syndrome Educational Trust Down Syndrome Research and Practice 1993, 1 (3) 123-128 Early intervention, a definition For the purpose of this article, early intervention will be defined as individualised, early, structured, long term support, either at home or in a centre. In the great majority of cases it will be carried out in accordance with a specific early intervention ...
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